Comparative Efficiency of Zinc Oxide Nanoparticles Ointment and Zinc Oxide Ointment Commercially Available for the Healing of Wounds in Rabbit (Oryctolagus Cuniculus)

Abstract

Skin is a protective layer of the body of all living organisms & saves the internal organs of the body from the external environment which may damage it. The damage in the continuity of skin is termed as wound & it causes exposure of internal body organs to the external environment which can be fetal for life. Skin automatically starts wound healing process. We can assist this process by keeping it germ, dust & moisture free with the help of topical applications of different agents e.g., zinc oxide. It controls the contamination of wound from bacteria e.g., Escherichia coli and Staphylococcus aureus, which can delay healing process. There is a hypothesis that when zinc oxide is converted to nanoparticles, it can increase the heeling efficiency of wound because these nanoparticles penetrate well in wound. The current study aimed to compare the efficacy of Zn2O nanoparticles ointment to commercially available for the healing of 2nd degree chemical burn cutaneous wounds. During this study, 3 wounds were inflicted on each rabbit group named as A, B & C (control group). Zinc oxide nanoparticles were used for Group A, commercially available Zn2O for group B & for group C normal saline. By checking healing time, histopathology and contraction rate, the result of different treatments were judged. To infer the decision, the overall efficacy of all medication on the respective wounds was assessed and comparison was done with each other.