Exploring the Role of Non-Coding RNAs in Cardiovascular Disease and its Determinants-A Comprehensive Study

Abstract

Background: Globally, cardiovascular illnesses are vital source of morbidity and mortality, and RNA that don’t code protein have been corresponding the pathology of Cardiovascular disease and has emerged as important mediators of expression of genes. Objectives: The purpose of present research was to explore the potential of non-coding RNAs as prognostic and diagnostic biomarkers through investigating their levels of expression in both healthy controls and patients with cardiovascular disease. Methodology: In this study, 26 cardiovascular diseases patients and other healthy controls were enrolled. Quantitative real-time PCR and sequencing of RNA were used to profile non-coding RNA expression. To find variations in non-coding RNA and their possible objectives, bioinformatics techniques and statistical investigation were employed. Results: In compare cardiovascular disease patients to healthy controls, there were 26 non-coding RNA that were expressed significantly. Many physiological processes, such as inflammation, replication of cells, and death, were affected by these non-coding RNA. The results of our research concluded that non-coding RNA have a high level of specificity and sensitivity for differentiating both healthy controls and patients with CVD. Conclusion: In addition to identifying possible therapeutic and prognostic indicators, this research gives new knowledge into the role of non-coding RNA in Cardiovascular disease. More investigation will be needed for authenticate results and examine the possible medical advantages of non-coding RNA treatment in cardiovascular disease. Keywords: Cardiovascular disease, Non coding RNA, Micro RNA, long non coding RNA.